Alberto Navarro-Navajas, Departamento de Cardiología, Fundación Cardioinfantil-LaCardio, Bogotá, Colombia
Lukas Salazar-Sierra, Departamento de Cardiología, Fundación Cardioinfantil-LaCardio, Bogotá, Colombia
Jorge Bustos-Martínez, Departamento de Cardiología, Fundación Cardioinfantil-LaCardio, Bogotá, Colombia
Darío Echeverri-Arcila, Departamento de Cardiología Intervencionista, Fundación Cardioinfantil-LaCardio, Bogotá, Colombia
Jaime Cabrales-Arévalo, Departamento de Cardiología Intervencionista, Fundación Cardioinfantil-LaCardio, Bogotá, Colombia
Juan H. del Portillo-Navarrete, Departamento de Cardiología Intervencionista, Fundación Cardioinfantil-LaCardio, Bogotá, Colombia
Guillermo Sarta-García, Facultad de Medicina, Universidad del Rosario. Bogotá, Colombia
Background: Previous studies have suggested an association between COVID-19 and acute coronary syndrome (ACS), though clinical and angiographic characteristics of these patients are not extensively described. Objective: To describe clinical and angiographic characteristics in a population of Colombian patients with ACS and a positive test for SARS-CoV-2 who underwent coronary angiography at a hospital in Bogotá, Colombia. Method: A descriptive, cross-sectional study was conducted on adults admitted to a Colombian hospital from March 6 to August 31, 2020, diagnosed with ACS and a positive RT-PCR test for SARS-CoV-2, or who developed ACS up to 14 days after testing positive. Results: The study population had an average age of 65 ± 13.9 years, with 59% being male. Non-ST elevation myocardial infarction was the most common diagnosis (46%, n = 12), followed by ST-elevation myocardial infarction (35%, n = 10) and unstable angina (19%, n = 5). Coronary arteriography showed atherosclerotic lesions in 59% of cases (n = 16), sub-occlusive thrombi in 26% (n = 8), and occlusive thrombi in 11% (n = 3). Conclusions: Most coronary lesions were atherosclerotic in nature, with 37% of patients having associated coronary thromboses. These findings suggest that SARS-CoV-2 infection may induce a hypercoagulable state and inflammation, contributing to thrombus formation and plaque destabilization, respectively.
Keywords: SARS-CoV-2. Acute coronary syndrome. Coronary angiography. COVID-19.